ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

P2ry12

Full Name:

purinergic receptor P2Y, G-protein coupled 12

Alias:

P2y12

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

2q31

Physical Location:

148611034-148613984 on NC_005101.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 64805 Symbol (Name): P2RY12 (purinergic receptor P2Y, G-protein coupled, 12)

Ortholog Status:

The human GeneID 64805 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		P2ry12
Fold Change:		1.12
P Value:		0.01
Note:		Differential expression between ethanol and saccharin groups in amygdala

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_022800.1	NP_073637.1	NC_005101.2 range: 148611034..148613984, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005886	plasma membrane	Cellular Component	IEA
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0005886	plasma membrane	Cellular Component	IMP (11196645)
GO:0001609	adenosine receptor activity, G-protein coupled	Molecular Function	IEA
GO:0004872	receptor activity	Molecular Function	IEA
GO:0001621	platelet ADP receptor activity	Molecular Function	ISS
GO:0001621	platelet ADP receptor activity	Molecular Function	IEA
GO:0001621	platelet ADP receptor activity	Molecular Function	IDA (11196645)
GO:0001609	adenosine receptor activity, G-protein coupled	Molecular Function	ISS
GO:0030168	platelet activation	Biological Process	ISS
GO:0030168	platelet activation	Biological Process	IEA
GO:0007194	negative regulation of adenylate cyclase activity	Biological Process	NAS (11196645)
GO:0007188	G-protein signaling, coupled to cAMP nucleotide second messenger	Biological Process	ISS
GO:0007188	G-protein signaling, coupled to cAMP nucleotide second messenger	Biological Process	IEA
GO:0007186	G-protein coupled receptor protein signaling pathway	Biological Process	IMP (11196645)
GO:0007186	G-protein coupled receptor protein signaling pathway	Biological Process	IEA
GO:0007165	signal transduction	Biological Process	IEA
GO:0043491	protein kinase B signaling cascade	Biological Process	IMP (15056287)