ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Kcnd3

Full Name:

potassium voltage gated channel, Shal-related family, member 3

Alias:

Kv4.3

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

2q34

Physical Location:

200716535-200924542 on NC_005101.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 3752 Symbol (Name): KCND3 (potassium voltage-gated channel, Shal-related subfamily, member 3)

Ortholog Status:

The human GeneID 3752 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Kcnd3
Fold Change:		1.16
P Value:		0.007
Note:		Differential expression between ethanol and saccharin groups in nucleus accumbens

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_031739.2	NP_113927.2	NC_005101.2 range: 200716535..200924542

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0043025	cell soma	Cellular Component	IDA (15738276)
GO:0043005	neuron projection	Cellular Component	IDA (15738276)
GO:0016020	membrane	Cellular Component	IEA
GO:0008076	voltage-gated potassium channel complex	Cellular Component	IEA
GO:0005887	integral to plasma membrane	Cellular Component	IDA (10325948)
GO:0005250	A-type (transient outward) potassium channel activity	Molecular Function	IMP (12150935)
GO:0005216	ion channel activity	Molecular Function	IEA
GO:0005249	voltage-gated potassium channel activity	Molecular Function	IDA (10325948)
GO:0005249	voltage-gated potassium channel activity	Molecular Function	IEA
GO:0005216	ion channel activity	Molecular Function	IDA (10325948)
GO:0005249	voltage-gated potassium channel activity	Molecular Function	IMP (12150935)
GO:0005515	protein binding	Molecular Function	IPI (10794667)
GO:0005267	potassium channel activity	Molecular Function	IDA (10325948)
GO:0006811	ion transport	Biological Process	IEA
GO:0006813	potassium ion transport	Biological Process	TAS (10325948)
GO:0006813	potassium ion transport	Biological Process	IEA