ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

B4galt6

Full Name:

UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 6

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

18p12

Physical Location:

12421061-12478275 on NC_005117.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 9331 Symbol (Name): B4GALT6 (UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6)

Ortholog Status:

The human GeneID 9331 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Rn.21126
Original ID2:		B4galt6
Fold Change:		1.44
P Value:		0.00001
Note:		Lower levels in the hippocampus of iP than iNP rats

Dataset Information

Name:		15660665
Method:		Microarray
Tissue:		Hippocampus
Phenotype:		Alcohol-preferring, alcohol-nonpreferring
Publication:		Edenberg et al. Genes Brain Behav. (2005) Gene expression in the hippocampus of inbred alcohol-preferring and -nonpreferring rats. PubMed
Summary:		The objective of this study was to test the hypothesis that there are innate differences in gene expression in the hippocampus of inbred alcohol-preferring (iP) and -nonpreferring (iNP) rats that may contribute to differences in sensitivity to ethanol and/or in the development of tolerance. Affymetrix microarrays were used to measure gene expression in the hippocampus of alcohol-naive male iP and iNP rats in two experiments (n = 4 and 6 per strain in the two experiments). Combining data from the two experiments, there were 137 probesets representing 129 genes that significantly differed (P ? 0.01).

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_031740.1	NP_113928.1	NC_005117.2 range: 12421061..12478275, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005794	Golgi apparatus	Cellular Component	IEA
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	IEA
GO:0000287	magnesium ion binding	Molecular Function	IEA
GO:0016757	transferase activity, transferring glycosyl groups	Molecular Function	IEA
GO:0008489	UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity	Molecular Function	IDA (9593693)
GO:0005509	calcium ion binding	Molecular Function	IEA
GO:0030145	manganese ion binding	Molecular Function	IEA
GO:0006688	glycosphingolipid biosynthetic process	Biological Process	TAS (9593693)
GO:0005975	carbohydrate metabolic process	Biological Process	IEA