ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

65199

Symbol:

Kcnip3

Full Name:

Kv channel interacting protein 3, calsenilin

Alias:

Csen|Dream|rKChIP3

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

3q36

Physical Location:

114961112-115025319 on NC_005102.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 30818 Symbol (Name): KCNIP3 (Kv channel interacting protein 3, calsenilin)

Ortholog Status:

The human GeneID 30818 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Csen
Fold Change:		-1.23
P Value:		0.008
Note:		Differential expression between ethanol and saccharin groups in nucleus accumbens

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_032462.1	NP_115851.1	NC_005102.2 range: 114961112..115025319, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005794	Golgi apparatus	Cellular Component	IEA
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0005634	nucleus	Cellular Component	ISS
GO:0005634	nucleus	Cellular Component	IEA
GO:0005829	cytosol	Cellular Component	ISS
GO:0005886	plasma membrane	Cellular Component	IEA
GO:0005783	endoplasmic reticulum	Cellular Component	IEA
GO:0030955	potassium ion binding	Molecular Function	IEA
GO:0016566	specific transcriptional repressor activity	Molecular Function	ISS
GO:0015459	potassium channel regulator activity	Molecular Function	IDA (12829703)
GO:0048306	calcium-dependent protein binding	Molecular Function	ISS
GO:0005515	protein binding	Molecular Function	IPI (16123112)
GO:0005509	calcium ion binding	Molecular Function	IEA
GO:0005267	potassium channel activity	Molecular Function	IEA
GO:0005244	voltage-gated ion channel activity	Molecular Function	IEA
GO:0003677	DNA binding	Molecular Function	ISS
GO:0008022	protein C-terminus binding	Molecular Function	ISS
GO:0048265	response to pain	Biological Process	ISS
GO:0043523	regulation of neuron apoptosis	Biological Process	ISS
GO:0019233	sensory perception of pain	Biological Process	ISS
GO:0007610	behavior	Biological Process	ISS
GO:0006915	apoptosis	Biological Process	IEA
GO:0006886	intracellular protein transport	Biological Process	IMP (12829703)
GO:0006813	potassium ion transport	Biological Process	IEA
GO:0006811	ion transport	Biological Process	IEA
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	IEA
GO:0006350	transcription	Biological Process	IEA
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	Biological Process	ISS