ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

SLC6A7

Full Name:

solute carrier family 6 (neurotransmitter transporter, L-proline), member 7

Alias:

PROT

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

5q31-q32

Physical Location:

149549712-149570827 on NC_000005.8

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

SLC6A7

Dataset Information

Name:		18477577
Method:		Addiction array gene list
Publication:		Hodgkinson et al. Alcohol Alcohol. (2008) Addictions Biology: Haplotype-Based Analysis for 130 Candidate Genes on a Single Array. PubMed
Summary:		To develop a panel of markers able to extract full haplotype information for candidate genes in alcoholism, other addictions and disorders of mood and anxiety. Methods: A total of 130 genes were haplotype tagged and genotyped in 7 case/control populations and 51 reference populations using Illumina GoldenGate SNP genotyping technology, determining haplotype coverage. The 130 candidate genes were selected on the basis of their roles in functional domains important in the addictions and in the related phenotypes of anxiety and depression. The candidate genes included a limited number involved in the pharmacokinetic domain (e.g. several genes in the ADH gene cluster, and ALDH genes). The majority of the genes represent the domains of vulnerability to drug use and pharmacodynamic response. These include dopamine, serotonin, glutamine, GABA, and opioid neurotransmitter genes, signaling genes, and genes modulating stress resiliency and behavioral dyscontrol domains. There is a high degree of overlap between functional gene categories because of pleiotropic actions of molecules on behavior.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_014228.3	NP_055043.2	NC_000005.8 range: 149549712..149570827

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005624	membrane fraction	Cellular Component	TAS (7651355)
GO:0005887	integral to plasma membrane	Cellular Component	TAS (7651355)
GO:0016020	membrane	Cellular Component	IEA
GO:0005328	neurotransmitter:sodium symporter activity	Molecular Function	IEA
GO:0015293	symporter activity	Molecular Function	IEA
GO:0006836	neurotransmitter transport	Biological Process	IEA
GO:0006865	amino acid transport	Biological Process	IEA
GO:0007268	synaptic transmission	Biological Process	NR
GO:0015824	proline transport	Biological Process	TAS (7651355)