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Gene Information
Gene ID:6539
Symbol:SLC6A12
Full Name:solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12
Alias:BGT-1|BGT1|FLJ38727
Organism:Homo sapiens (Human)
Chromosome:12
Genetic Location:12p13
Physical Location:169512-192752 on NC_000012.10, complement
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Hs.437174
Note:"Class II, up-regulated gene"
Dataset Information
Name:16292326
Method:Microarray
Tissue:Frontal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
Summary:In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_003044.3NP_003035.3NC_000012.10 range: 169512..192752, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005887integral to plasma membraneCellular ComponentIEA
GO:0016020membraneCellular ComponentIEA
GO:0005328neurotransmitter:sodium symporter activityMolecular FunctionIEA
GO:0005332gamma-aminobutyric acid:sodium symporter activityMolecular FunctionIEA
GO:0015293symporter activityMolecular FunctionIEA
GO:0006836neurotransmitter transportBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:6539
HGNC:11045
Ensembl:ENSG00000111181
MIM:603080
HPRD:04358
HuGE Navigator:6539
dbSNP:SLC6A12
GeneCard:SLC6A12
AceView:SLC6A12