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Gene Information
Gene ID:6558
Symbol:SLC12A2
Full Name:solute carrier family 12 (sodium/potassium/chloride transporters), member 2
Alias:BSC|BSC2|MGC104233|NKCC1
Organism:Homo sapiens (Human)
Chromosome:5
Genetic Location:5q23.3
Physical Location:127447381-127553278 on NC_000005.8
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Hs.162585
Note:"Class II, down-regulated gene"
Dataset Information
Name:16292326
Method:Microarray
Tissue:Frontal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
Summary:In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_001046.2NP_001037.1NC_000005.8 range: 127447381..127553278
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005624membrane fractionCellular ComponentTAS (7629105)
GO:0005887integral to plasma membraneCellular ComponentTAS (7629105)
GO:0016020membraneCellular ComponentIEA
GO:0005215transporter activityMolecular FunctionIEA
GO:0030955potassium ion bindingMolecular FunctionIEA
GO:0015293symporter activityMolecular FunctionIEA
GO:0008511sodium:potassium:chloride symporter activityMolecular FunctionTAS (7629105)
GO:0031402sodium ion bindingMolecular FunctionIEA
GO:0006814sodium ion transportBiological ProcessIEA
GO:0006813potassium ion transportBiological ProcessIEA
GO:0006811ion transportBiological ProcessIEA
GO:0006821chloride transportBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:6558
HGNC:10911
Ensembl:ENSG00000064651
MIM:600840
HPRD:06775
HuGE Navigator:6558
dbSNP:SLC12A2
GeneCard:SLC12A2
AceView:SLC12A2