ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Ube2d3

Full Name:

ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)

Alias:

1100001F19Rik|9430029A22Rik|AA414951

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

3 G3

Physical Location:

135101722-135130141 on NC_000069.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 7323 Symbol (Name): UBE2D3 (ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast))

Ortholog Status:

The human GeneID 7323 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Ube2d3
Original ID2:		AI847826

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_025356.4	NP_079632.1	NC_000069.5 range: 135101722..135130141

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0004842	ubiquitin-protein ligase activity	Molecular Function	RCA (16141072)
GO:0016874	ligase activity	Molecular Function	IEA
GO:0019787	small conjugating protein ligase activity	Molecular Function	IEA
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	RCA (16141072)
GO:0006512	ubiquitin cycle	Biological Process	IEA
GO:0043161	proteasomal ubiquitin-dependent protein catabolic process	Biological Process	IDA (15601779)
GO:0043687	post-translational protein modification	Biological Process	IEA
GO:0051246	regulation of protein metabolic process	Biological Process	IEA