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Gene Information
Gene ID:66105
Full Name:ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)
Organism:Mus musculus (Mouse)
Genetic Location:3 G3
Physical Location:135101722-135130141 on NC_000069.5
Gene Type:protein-coding
Human Ortholog:GeneID: 7323    Symbol (Name): UBE2D3 (ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast))
Ortholog Status:The human GeneID 7323 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Ube2d3
Original ID2:AI847826
Dataset Information
Tissue:Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:Acute ethanol response
Publication:Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_025356.4NP_079632.1NC_000069.5 range: 135101722..135130141
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0004842ubiquitin-protein ligase activityMolecular FunctionRCA (16141072)
GO:0016874ligase activityMolecular FunctionIEA
GO:0019787small conjugating protein ligase activityMolecular FunctionIEA
GO:0006511ubiquitin-dependent protein catabolic processBiological ProcessRCA (16141072)
GO:0006512ubiquitin cycleBiological ProcessIEA
GO:0043161proteasomal ubiquitin-dependent protein catabolic processBiological ProcessIDA (15601779)
GO:0043687post-translational protein modificationBiological ProcessIEA
GO:0051246regulation of protein metabolic processBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:66105