ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Cox7b

Full Name:

cytochrome c oxidase subunit VIIb

Alias:

1100001F07Rik|1110004F07Rik|C80563|MGC107263

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

X C3

Physical Location:

103211038-103217788 on NC_000086.6

Gene Type:

protein-coding

Human Ortholog:

GeneID: 1349 Symbol (Name): COX7B (cytochrome c oxidase subunit VIIb)

Ortholog Status:

The human GeneID 1349 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Cox7b
Original ID2:		AI851220

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_025379.2	NP_079655.1	NC_000086.6 range: 103211038..103217788

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005739	mitochondrion	Cellular Component	IDA (14651853)
GO:0005746	mitochondrial respiratory chain	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	IEA
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0004129	cytochrome-c oxidase activity	Molecular Function	IEA