ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

SOD2

Full Name:

superoxide dismutase 2, mitochondrial

Alias:

IPO-B|MNSOD|Mn-SOD

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

6q25.3

Physical Location:

160020137-160034342 on NC_000006.10, complement

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 20656 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

SOD2

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene Information

HuGE Navigator Dataset

Name:		HuGE Navigator
Method:		Literature data mining
Publication:		Wei Yu, Melinda Clyne, Anja Wulf, Ajay Yesupriya, Marta Gwinn and Muin J. Khoury. Phenopedia. HuGE Navigator. Available at: http://www.hugenavigator.net/HuGENavigator/startPagePhenoPedia.do. Accessed [Jun. 10, 2008].
Summary:		HuGE Navigator Phenopedia provides a disease-centered view of genetic association studies summarized in the online Human Genome Epidemiology (HuGE) encyclopedia. We extracted genes associated to 9 Alcohol-related diseases (Alcohol Amnestic Disorder; Alcohol Withdrawal Delirium; Alcohol Withdrawal Seizures; Alcohol-Induced Disorders; Alcohol-Induced Disorders, Nervous System; Alcohol-Related Disorders; Alcoholic Intoxication; Alcoholic Neuropathy; Alcoholism) from HuGE Navigator Phenopedia.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005739	mitochondrion	Cellular Component	TAS (15087454)
GO:0005759	mitochondrial matrix	Cellular Component	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0030145	manganese ion binding	Molecular Function	IEA
GO:0016491	oxidoreductase activity	Molecular Function	IEA
GO:0004784	superoxide dismutase activity	Molecular Function	IDA (14980699)
GO:0004784	superoxide dismutase activity	Molecular Function	IEA
GO:0006979	response to oxidative stress	Biological Process	TAS (9462746)
GO:0006801	superoxide metabolic process	Biological Process	IEA
GO:0006801	superoxide metabolic process	Biological Process	IDA (14980699)
GO:0006357	regulation of transcription from RNA polymerase II promoter	Biological Process	ISS
GO:0006357	regulation of transcription from RNA polymerase II promoter	Biological Process	IMP (9393747)
GO:0001315	age-dependent response to reactive oxygen species	Biological Process	ISS
GO:0001315	age-dependent response to reactive oxygen species	Biological Process	IMP (14980699)
GO:0000303	response to superoxide	Biological Process	TAS (9462746)