Logo
Home Search BLAST Integration Document Link Support Citation

Gene Information
Gene ID:20656
Symbol:Sod2
Full Name:superoxide dismutase 2, mitochondrial
Alias:MGC6144|MnSOD|Sod-2
Organism:Mus musculus (Mouse)
Chromosome:17
Genetic Location:17 A1|17 7.6 cM
Physical Location:13200704-13210984 on NC_000083.5
Gene Type:protein-coding
Human Ortholog:GeneID: 6648    Symbol (Name): SOD2 (superoxide dismutase 2, mitochondrial)
Ortholog Status:The human GeneID 6648 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Sod2
Original ID2:L35528
Dataset Information
Name:15745951
Method:Microarray
Tissue:Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:Acute ethanol response
Publication:Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.
Gene Information
Original ID1:Sod2
Fold Change:0.71
Note:Significantly regulated by ethanol in cortical neurons
Gene Information
Original ID1:Sod2
Fold Change:0.74
Note:Significantly regulated in cortical neurons treated with both ethanol and nicotine
Dataset Information
Name:17295719
Method:Microarray
Tissue:Cultured fetal mouse cortical neurons
Phenotype:Ethanol response
Publication:Wang et al. Alcohol Clin Exp Res. (2007) Regulation of platelet-derived growth factor signaling pathway by ethanol, nicotine, or both in mouse cortical neurons. PubMed
Summary:By using cultured fetal mouse cortical neurons as a model system, we sought to identify genes and pathways that are modulated in the cells by ethanol, nicotine, or both. METHODS: Primary cerebral cortical cultures were prepared from the brains of 14-day-old C57BL/6 mouse fetuses and exposed to ethanol (75 mM), nicotine (0.1 mM), or both for 5 consecutive days. A homeostatic pathway-focused microarray consisting of 638 sequence-verified genes was used to measure transcripts differentially regulated by ethanol, nicotine, or both in 5 drug-treated cortical neuron samples and 5 control samples. We identified 65, 111, and 81 significantly regulated genes in the ethanol, nicotine, and ethanol/nicotine-treated neurons, respectively. A gene was considered to be significantly regulated if (1) the fold change was 20% greater or less compared with the controls and (2) the difference was p<0.05 by Student's t-test.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_013671.3NP_038699.2NC_000083.5 range: 13200704..13210984
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005739mitochondrionCellular ComponentIDA (11583975|12931191|14651853|16103131|17597094)
GO:0005743mitochondrial inner membraneCellular ComponentIDA (12865426)
GO:0016491oxidoreductase activityMolecular FunctionIEA
GO:0030145manganese ion bindingMolecular FunctionIEA
GO:0046872metal ion bindingMolecular FunctionIEA
GO:0004784superoxide dismutase activityMolecular FunctionIMP (12176043|15182862)
GO:0004784superoxide dismutase activityMolecular FunctionIDA (12646716)
GO:0042542response to hydrogen peroxideBiological ProcessIMP (15642323)
GO:0043066negative regulation of apoptosisBiological ProcessIMP (15642323)
GO:0010332response to gamma radiationBiological ProcessIGI (15182862)
GO:0006979response to oxidative stressBiological ProcessIMP (15182862)
GO:0006979response to oxidative stressBiological ProcessIGI (15182862|17322295)
GO:0006801superoxide metabolic processBiological ProcessIMP (12176043)
GO:0006302double-strand break repairBiological ProcessIMP (15642323)
GO:0001836release of cytochrome c from mitochondriaBiological ProcessIMP (15642323)
GO:0000303response to superoxideBiological ProcessIMP (15642323)
GO:0000302response to reactive oxygen speciesBiological ProcessIMP (17145560)
Other Database Cross Links
NCBI Entrez Gene:20656
MGI:
Ensembl:ENSMUSG00000006818
dbSNP:Sod2
AceView:Sod2