ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Ppp1r2

Full Name:

protein phosphatase 1, regulatory (inhibitor) subunit 2

Alias:

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

16 B2

Physical Location:

31251626-31275362 on NC_000082.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 5504 Symbol (Name): PPP1R2 (protein phosphatase 1, regulatory (inhibitor) subunit 2)

Ortholog Status:

The human GeneID 5504 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Ppp1r2
Original ID2:		AW049584

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_025800.3	NP_080076.1	NC_000082.5 range: 31251626..31275362, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0004864	protein phosphatase inhibitor activity	Molecular Function	IEA
GO:0005975	carbohydrate metabolic process	Biological Process	IEA
GO:0005977	glycogen metabolic process	Biological Process	IEA
GO:0009966	regulation of signal transduction	Biological Process	IEA
GO:0043666	regulation of phosphoprotein phosphatase activity	Biological Process	IEA