ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Pcyox1

Full Name:

prenylcysteine oxidase 1

Alias:

1200015P13Rik|AI115532|AI448340|PCL1|Pcly

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

6 D1

Physical Location:

86336850-86347113 on NC_000072.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 51449 Symbol (Name): PCYOX1 (prenylcysteine oxidase 1)

Ortholog Status:

The human GeneID 51449 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Pcyox1
Original ID2:		AI850953

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_025823.4	NP_080099.1	NC_000072.5 range: 86336850..86347113, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005615	extracellular space	Cellular Component	RCA (12466851)
GO:0005764	lysosome	Cellular Component	IEA
GO:0001735	prenylcysteine oxidase activity	Molecular Function	IMP (12151402)
GO:0009055	electron carrier activity	Molecular Function	IEA
GO:0016491	oxidoreductase activity	Molecular Function	IEA
GO:0030328	prenylcysteine catabolic process	Biological Process	IMP (12151402)