ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

SPTBN2

Full Name:

spectrin, beta, non-erythrocytic 2

Alias:

GTRAP41|SCA5

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

11q13

Physical Location:

66209298-66245445 on NC_000011.8, complement

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 20743 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		AB008567
Fold Change:		1.4, 1.5
Note:		Differential Expression on the cDNA array (two fold changes are from two case groups)

Dataset Information

Name:		11141048
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Lewohl et al. Alcohol Clin Exp Res. (2000) Gene expression in human alcoholism: microarray analysis of frontal cortex. PubMed
Summary:		RNA was extracted from postmortem samples of superior frontal cortex of alcoholics and nonalcoholics. Relative levels of RNA were determined by array techniques. This study used both cDNA and oligonucleotide microarrays to provide coverage of a large number of genes and to allow cross-validation for those genes represented on both types of arrays. Expression levels were determined for over 4000 genes and 163 of these were found to differ by 40% or more between alcoholics and nonalcoholics.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_006946.1	NP_008877.1	NC_000011.8 range: 66209298..66245445, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0005856	cytoskeleton	Cellular Component	IEA
GO:0008091	spectrin	Cellular Component	IEP (9826670)
GO:0003779	actin binding	Molecular Function	TAS (9826670)
GO:0005200	structural constituent of cytoskeleton	Molecular Function	TAS (9826670)
GO:0008219	cell death	Biological Process	IEA
GO:0016192	vesicle-mediated transport	Biological Process	IDA (9826670)
GO:0051016	barbed-end actin filament capping	Biological Process	IEA