ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

SREBF1

Full Name:

sterol regulatory element binding transcription factor 1

Alias:

SREBP1

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

17p11.2

Physical Location:

17656110-17681049 on NC_000017.9, complement

Gene Type:

protein-coding

Orthologs:

This gene has Rat: 78968 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

SREBF1

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Linkage Dataset

Marker

LOD

P value

Location (bp)

D17S1857

16355942

Region:		14355942-18355942
Phenotype:		Alcoholism phenotype along with age, gender, and P300 or constraint
Name:		15211641
Method:		Linkage
Publication:		Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:		A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0000139	Golgi membrane	Cellular Component	IEA
GO:0031410	cytoplasmic vesicle	Cellular Component	IEA
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	IEA
GO:0005634	nucleus	Cellular Component	TAS (8156598)
GO:0005635	nuclear envelope	Cellular Component	TAS (8156598)
GO:0005783	endoplasmic reticulum	Cellular Component	IEA
GO:0005789	endoplasmic reticulum membrane	Cellular Component	TAS (8156598)
GO:0005794	Golgi apparatus	Cellular Component	IEA
GO:0032810	sterol response element binding	Molecular Function	IDA (16407292)
GO:0005515	protein binding	Molecular Function	IPI (16799563)
GO:0003702	RNA polymerase II transcription factor activity	Molecular Function	TAS (8156598)
GO:0003700	transcription factor activity	Molecular Function	IDA (16407292)
GO:0006629	lipid metabolic process	Biological Process	TAS (8156598)
GO:0008202	steroid metabolic process	Biological Process	IEA
GO:0008203	cholesterol metabolic process	Biological Process	IEA
GO:0009267	cellular response to starvation	Biological Process	ISS (16407292)
GO:0006357	regulation of transcription from RNA polymerase II promoter	Biological Process	TAS (8156598)