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Gene Information
Gene ID:6720
Full Name:sterol regulatory element binding transcription factor 1
Organism:Homo sapiens (Human)
Genetic Location:17p11.2
Physical Location:17656110-17681049 on NC_000017.9, complement
Gene Type:protein-coding
Orthologs:This gene has Rat: 78968 ortholog(s) in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:SREBF1
Dataset Information
Name:Literature Search
Method:Literature search
Summary:We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.
Linkage Dataset
MarkerLODP valueLocation (bp)
D17S1857  16355942
Phenotype:Alcoholism phenotype along with age, gender, and P300 or constraint
Publication:Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_001005291.1NP_001005291.1NC_000017.9 range: 17656110..17681049, complement
NM_004176.3NP_004167.3NC_000017.9 range: 17656110..17681049, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0000139Golgi membraneCellular ComponentIEA
GO:0031410cytoplasmic vesicleCellular ComponentIEA
GO:0016021integral to membraneCellular ComponentIEA
GO:0016020membraneCellular ComponentIEA
GO:0005634nucleusCellular ComponentTAS (8156598)
GO:0005635nuclear envelopeCellular ComponentTAS (8156598)
GO:0005783endoplasmic reticulumCellular ComponentIEA
GO:0005789endoplasmic reticulum membraneCellular ComponentTAS (8156598)
GO:0005794Golgi apparatusCellular ComponentIEA
GO:0032810sterol response element bindingMolecular FunctionIDA (16407292)
GO:0005515protein bindingMolecular FunctionIPI (16799563)
GO:0003702RNA polymerase II transcription factor activityMolecular FunctionTAS (8156598)
GO:0003700transcription factor activityMolecular FunctionIDA (16407292)
GO:0006629lipid metabolic processBiological ProcessTAS (8156598)
GO:0008202steroid metabolic processBiological ProcessIEA
GO:0008203cholesterol metabolic processBiological ProcessIEA
GO:0009267cellular response to starvationBiological ProcessISS (16407292)
GO:0006357regulation of transcription from RNA polymerase II promoterBiological ProcessTAS (8156598)
Other Database Cross Links
NCBI Entrez Gene:6720
HuGE Navigator:6720