ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Srebf1

Full Name:

sterol regulatory element binding factor 1

Alias:

ADD-1|Srebp1

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

10q22

Physical Location:

46460550-46483703 on NC_005109.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 6720 Symbol (Name): SREBF1 (sterol regulatory element binding transcription factor 1)

Ortholog Status:

The human GeneID 6720 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Srebf1
Fold Change:		1.14
P Value:		0.003
Note:		Differential expression between ethanol and saccharin groups in nucleus accumbens

Dataset Information

Name:		18405950
Method:		Microarray
Tissue:		Nucleus accumbens and amygdala
Phenotype:		Ethanol self-administration, alcohol-preferring
Publication:		Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:		The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
XM_213329.4	XP_213329.4	NC_005109.2 range: 46460550..46483703, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	ISS
GO:0005634	nucleus	Cellular Component	IDA (15944339)
GO:0032810	sterol response element binding	Molecular Function	ISS
GO:0003677	DNA binding	Molecular Function	ISS
GO:0005515	protein binding	Molecular Function	ISS
GO:0003704	specific RNA polymerase II transcription factor activity	Molecular Function	IDA (16055439)
GO:0003700	transcription factor activity	Molecular Function	ISS
GO:0008610	lipid biosynthetic process	Biological Process	TAS (12036955)
GO:0009267	cellular response to starvation	Biological Process	ISS
GO:0045449	regulation of transcription	Biological Process	ISS