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Gene Information
Gene ID:78968
Full Name:sterol regulatory element binding factor 1
Organism:Rattus norvegicus (Rat)
Genetic Location:10q22
Physical Location:46460550-46483703 on NC_005109.2, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 6720    Symbol (Name): SREBF1 (sterol regulatory element binding transcription factor 1)
Ortholog Status:The human GeneID 6720 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Srebf1
Fold Change:1.14
P Value:0.003
Note:Differential expression between ethanol and saccharin groups in nucleus accumbens
Dataset Information
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
XM_213329.4XP_213329.4NC_005109.2 range: 46460550..46483703, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005634nucleusCellular ComponentISS
GO:0005634nucleusCellular ComponentIDA (15944339)
GO:0032810sterol response element bindingMolecular FunctionISS
GO:0003677DNA bindingMolecular FunctionISS
GO:0005515protein bindingMolecular FunctionISS
GO:0003704specific RNA polymerase II transcription factor activityMolecular FunctionIDA (16055439)
GO:0003700transcription factor activityMolecular FunctionISS
GO:0008610lipid biosynthetic processBiological ProcessTAS (12036955)
GO:0009267cellular response to starvationBiological ProcessISS
GO:0045449regulation of transcriptionBiological ProcessISS
Other Database Cross Links
NCBI Entrez Gene:78968