ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Mosc2

Full Name:

MOCO sulphurase C-terminal domain containing 2

Alias:

2810484M10Rik

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

1 H4

Physical Location:

186636946-186669725 on NC_000067.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 54996 Symbol (Name): MOSC2 (MOCO sulphurase C-terminal domain containing 2)

Ortholog Status:

The human GeneID 54996 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		2810484M10Rik
Original ID2:		AW124268

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_133684.3	NP_598445.1	NC_000067.5 range: 186636946..186669725, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016021	integral to membrane	Cellular Component	RCA (12466851)
GO:0005615	extracellular space	Cellular Component	RCA (12466851)
GO:0005739	mitochondrion	Cellular Component	IDA (14651853)
GO:0005743	mitochondrial inner membrane	Cellular Component	IDA (12865426)
GO:0016020	membrane	Cellular Component	IEA
GO:0019867	outer membrane	Cellular Component	IEA
GO:0030151	molybdenum ion binding	Molecular Function	IEA
GO:0016491	oxidoreductase activity	Molecular Function	IEA
GO:0003824	catalytic activity	Molecular Function	IEA
GO:0030170	pyridoxal phosphate binding	Molecular Function	IEA