ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

SRP72

Full Name:

signal recognition particle 72kDa

Organism:

Homo sapiens (Human)

Chromosome:

4

Genetic Location:

4q11

Physical Location:

57028518-57064603 on NC_000004.10

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Hs.237825
Note:		"Class II, up-regulated gene"

Dataset Information

Name:		16292326
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
Summary:		In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_006947.3	NP_008878.3	NC_000004.10 range: 57028518..57064603

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0048500	signal recognition particle	Cellular Component	IEA
GO:0005730	nucleolus	Cellular Component	IDA (10618370)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0005786	signal recognition particle, endoplasmic reticulum targeting	Cellular Component	IEA
GO:0016301	kinase activity	Molecular Function	IEA
GO:0008312	7S RNA binding	Molecular Function	IEA
GO:0004871	signal transducer activity	Molecular Function	NAS (9224693)
GO:0005488	binding	Molecular Function	IEA
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	Biological Process	IEA
GO:0007165	signal transduction	Biological Process	TAS (9224693)
GO:0006468	protein amino acid phosphorylation	Biological Process	TAS (9224693)

Other Database Cross Links

NCBI Entrez Gene:

HGNC:

Ensembl:

ENSG00000174780

MIM:

HPRD:

HuGE Navigator:

dbSNP:

GeneCard:

AceView: