ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Pdlim7

Full Name:

PDZ and LIM domain 7

Alias:

1110003B01Rik|2410002J21Rik|AV007930|Enigma

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

13 B2

Physical Location:

55608133-55614794 on NC_000079.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 9260 Symbol (Name): PDLIM7 (PDZ and LIM domain 7 (enigma))

Ortholog Status:

The human GeneID 9260 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Pdlim7
Original ID2:		AW125223

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_026131.3	NP_080407.3	NC_000079.5 range: 55608133..55614794, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005856	cytoskeleton	Cellular Component	IEA
GO:0001725	stress fiber	Cellular Component	IDA (15946664)
GO:0001726	ruffle	Cellular Component	IDA (15946664)
GO:0005737	cytoplasm	Cellular Component	IDA (15946664)
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (15946664)
GO:0007275	multicellular organismal development	Biological Process	IEA
GO:0030036	actin cytoskeleton organization and biogenesis	Biological Process	IPI (15946664)
GO:0030154	cell differentiation	Biological Process	IEA
GO:0001503	ossification	Biological Process	IEA