ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Dusp6

Full Name:

dual specificity phosphatase 6

Alias:

1300019I03Rik|MGC98540|MKP-3|MKP3|PYST1

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

10 C3

Physical Location:

98725864-98730117 on NC_000076.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 1848 Symbol (Name): DUSP6 (dual specificity phosphatase 6)

Ortholog Status:

The human GeneID 1848 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Dusp6
Original ID2:		AI845584

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_026268.2	NP_080544.1	NC_000076.5 range: 98725864..98730117

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0004721	phosphoprotein phosphatase activity	Molecular Function	IDA (15284227)
GO:0016791	phosphoric monoester hydrolase activity	Molecular Function	IEA
GO:0016787	hydrolase activity	Molecular Function	IEA
GO:0008138	protein tyrosine/serine/threonine phosphatase activity	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (15284227)
GO:0004725	protein tyrosine phosphatase activity	Molecular Function	IEA
GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity	Molecular Function	IEA
GO:0006470	protein amino acid dephosphorylation	Biological Process	IDA (15284227)
GO:0016311	dephosphorylation	Biological Process	IEA