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Gene Information
Gene ID:67603
Full Name:dual specificity phosphatase 6
Organism:Mus musculus (Mouse)
Genetic Location:10 C3
Physical Location:98725864-98730117 on NC_000076.5
Gene Type:protein-coding
Human Ortholog:GeneID: 1848    Symbol (Name): DUSP6 (dual specificity phosphatase 6)
Ortholog Status:The human GeneID 1848 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Dusp6
Original ID2:AI845584
Dataset Information
Tissue:Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:Acute ethanol response
Publication:Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_026268.2NP_080544.1NC_000076.5 range: 98725864..98730117
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005737cytoplasmCellular ComponentIEA
GO:0004721phosphoprotein phosphatase activityMolecular FunctionIDA (15284227)
GO:0016791phosphoric monoester hydrolase activityMolecular FunctionIEA
GO:0016787hydrolase activityMolecular FunctionIEA
GO:0008138protein tyrosine/serine/threonine phosphatase activityMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionIPI (15284227)
GO:0004725protein tyrosine phosphatase activityMolecular FunctionIEA
GO:0017017MAP kinase tyrosine/serine/threonine phosphatase activityMolecular FunctionIEA
GO:0006470protein amino acid dephosphorylationBiological ProcessIDA (15284227)
GO:0016311dephosphorylationBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:67603