ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Sfrs6

Full Name:

splicing factor, arginine/serine-rich 6

Alias:

1210001E11Rik|AI314910|AW146126

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

2 H2|2 79.8 cM

Physical Location:

162757280-162762856 on NC_000068.6

Gene Type:

protein-coding

Human Ortholog:

GeneID: 6431 Symbol (Name): SFRS6 (splicing factor, arginine/serine-rich 6)

Ortholog Status:

The human GeneID 6431 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		AI846595
Fold Change:		-1.6, -1.6, -1.6, -1
Note:		4 fold changes are from C57BL/6J trial 1, C57BL/6J trial 2, DBA/2J trial 1, DBA/2J trial 2

Dataset Information

Name:		15002731
Method:		Microarray
Tissue:		Whole brain
Phenotype:		Acute ethanol response
Publication:		Treadwell et al. Neurochem Res. (2004) Microarray analysis of mouse brain gene expression following acute ethanol treatment. PubMed
Summary:		We have analyzed the expression of approximately 24,000 genes using oligonucleotide microarrays to examine the brain expression profiles in two strains of inbred mice, C57BL/6J and DBA/2J, following exposure to an acute dose of ethanol. Our screen identified 61 genes responding to the ethanol treatment beyond a 1.5-fold threshold, with 46 genes altered in both mouse strains and 15 altered in only one strain.

QTL Information

QTL	Phenotype	Chr	Peak (cM)	LOD	P Value	Range	Status	QTL Link
Lore2	Alcohol-induced Loss of Righting Reflex	2		75.6-81.7 (cM)	6.6		Significant	PARC

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_026499.3	NP_080775.2	NC_000068.6 range: 162757280..162762856

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	RCA (16141072)
GO:0003677	DNA binding	Molecular Function	RCA (16141072)
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	RCA (16141072)