ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Dynll2

Full Name:

dynein light chain LC8-type 2

Alias:

1700064A15Rik|6720463E02Rik|C87222|Dlc2

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

11 C

Physical Location:

87793034-87801006 on NC_000077.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 140735 Symbol (Name): DYNLL2 (dynein, light chain, LC8-type 2)

Ortholog Status:

The human GeneID 140735 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		6720463E02Rik
Original ID2:		AI836322

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_026556.3	NP_080832.1	NC_000077.5 range: 87793034..87801006, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005875	microtubule associated complex	Cellular Component	RCA (16141072)
GO:0030286	dynein complex	Cellular Component	NAS (14561217)
GO:0016459	myosin complex	Cellular Component	IDA (14561217)
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0005874	microtubule	Cellular Component	IEA
GO:0003774	motor activity	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (11546872)
GO:0003777	microtubule motor activity	Molecular Function	RCA (16141072)
GO:0007017	microtubule-based process	Biological Process	RCA (16141072)
GO:0046907	intracellular transport	Biological Process	NAS (14561217)