ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Nola1

Full Name:

nucleolar protein family A, member 1 (H/ACA small nucleolar RNPs)

Alias:

AA409823|AI326794|C430047J18Rik|GAR1

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

3 G3

Physical Location:

129527837-129534073 on NC_000069.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 54433 Symbol (Name): NOLA1 (nucleolar protein family A, member 1 (H/ACA small nucleolar RNPs))

Ortholog Status:

The human GeneID 54433 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Nola1
Original ID2:		AF022465

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_026578.2	NP_080854.1	NC_000069.5 range: 129527837..129534073, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0001651	dense fibrillar component	Cellular Component	ISS (11074001)
GO:0005634	nucleus	Cellular Component	IEA
GO:0005732	small nucleolar ribonucleoprotein complex	Cellular Component	IEA
GO:0030529	ribonucleoprotein complex	Cellular Component	IEA
GO:0003723	RNA binding	Molecular Function	IEA
GO:0030515	snoRNA binding	Molecular Function	ISS (11074001)
GO:0019843	rRNA binding	Molecular Function	IEA
GO:0008150	biological_process	Biological Process	ND
GO:0006364	rRNA processing	Biological Process	IEA
GO:0042254	ribosome biogenesis and assembly	Biological Process	IEA