ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

SYT1

Full Name:

synaptotagmin I

Alias:

DKFZp781D2042|P65|SVP65|SYT

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

12cen-q21

Physical Location:

78135413-78368973 on NC_000012.10

Gene Type:

protein-coding

Orthologs:

This gene has Rat: 25716 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Dataset Information

Name:		15816859
Method:		Microarray
Tissue:		Prefrontal cortex and nucleus accumbens
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Flatscher-Bader et al. J Neurochem.(2005) Alcohol-responsive genes in the frontal cortex and nucleus accumbens of human alcoholics. PubMed
Summary:		Genes with a mean fold change > 1.5 or < 0.7 were selected and annotated. Values are taken from microarray analysis and represent mean ratios of alcoholic cases compared with matched control cases(n = 6). P values were from t-test.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_005639.1	NP_005630.1	NC_000012.10 range: 78135413..78368973

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0008021	synaptic vesicle	Cellular Component	TAS (11438518)
GO:0016020	membrane	Cellular Component	IEA
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0030054	cell junction	Cellular Component	IEA
GO:0030666	endocytic vesicle membrane	Cellular Component	EXP (2446925)
GO:0031410	cytoplasmic vesicle	Cellular Component	IEA
GO:0045202	synapse	Cellular Component	IEA
GO:0017075	syntaxin-1 binding	Molecular Function	TAS (11438518)
GO:0050750	low-density lipoprotein receptor binding	Molecular Function	IDA (15082773)
GO:0005215	transporter activity	Molecular Function	IEA
GO:0005543	phospholipid binding	Molecular Function	TAS (1840599)
GO:0005509	calcium ion binding	Molecular Function	IEA
GO:0005545	phosphatidylinositol binding	Molecular Function	TAS (11438518)
GO:0005515	protein binding	Molecular Function	IPI (11438518)
GO:0005515	protein binding	Molecular Function	TAS (11438518)
GO:0005513	detection of calcium ion	Biological Process	TAS (11438518)
GO:0007269	neurotransmitter secretion	Biological Process	TAS (11438518)
GO:0017157	regulation of exocytosis	Biological Process	TAS (11438518)
GO:0006810	transport	Biological Process	IEA
GO:0007268	synaptic transmission	Biological Process	TAS (1840599)
GO:0051260	protein homooligomerization	Biological Process	TAS (11438518)