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Gene Information
Gene ID:25716
Symbol:Syt1
Full Name:synaptotagmin I
Alias:P65
Organism:Rattus norvegicus (Rat)
Chromosome:7
Genetic Location:7q21
Physical Location:47240795-47795678 on NC_005106.2, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 6857    Symbol (Name): SYT1 (synaptotagmin I)
Ortholog Status:The human GeneID 6857 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:25716
Fold Change:0.791
P Value:0.0005
Note:Fold change is average ratio of AA to ANA.
Dataset Information
Name:15846778
Method:Microarray
Tissue:Frontal cortex
Phenotype:Alcohol-preferring, alcohol-nonpreferring
Publication:Worst et al. J Neurosci Res. (2005) Transcriptome analysis of frontal cortex in alcohol-preferring and nonpreferring rats. PubMed
Summary:DNA macroarrays were used to probe for differences in normative cortical gene expression between rat strains genetically selected for alcohol selfadministration preference, AA (Alko, alcohol) and P (Indiana, preferring), or avoidance, ANA (Alko, nonalcohol) and NP (Indiana, nonpreferring). Among 1,176 genes studied, six demonstrated confirmable, differential expression following comparison of ethanol-naive AA and ANA rats.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_001033680.2NP_001028852.2NC_005106.2 range: 47240795..47795678, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0030141secretory granuleCellular ComponentIEA
GO:0030141secretory granuleCellular ComponentISS
GO:0030672synaptic vesicle membraneCellular ComponentISS
GO:0030054cell junctionCellular ComponentIEA
GO:0030672synaptic vesicle membraneCellular ComponentTAS (2333096)
GO:0031410cytoplasmic vesicleCellular ComponentIEA
GO:0016021integral to membraneCellular ComponentIEA
GO:0042734presynaptic membraneCellular ComponentIEA
GO:0042734presynaptic membraneCellular ComponentISS
GO:0005737cytoplasmCellular ComponentTAS (2333096)
GO:0005737cytoplasmCellular ComponentIDA
GO:0043005neuron projectionCellular ComponentIEA
GO:0043005neuron projectionCellular ComponentISS
GO:0045202synapseCellular ComponentIEA
GO:0030672synaptic vesicle membraneCellular ComponentIEA
GO:0042802identical protein bindingMolecular FunctionIPI
GO:0048306calcium-dependent protein bindingMolecular FunctionISS
GO:0050750low-density lipoprotein receptor bindingMolecular FunctionIEA
GO:0005215transporter activityMolecular FunctionIEA
GO:0005509calcium ion bindingMolecular FunctionIEA
GO:0005509calcium ion bindingMolecular FunctionISS
GO:0005509calcium ion bindingMolecular FunctionTAS (2333096)
GO:0005516calmodulin bindingMolecular FunctionIDA (2333096)
GO:0005543phospholipid bindingMolecular FunctionIDA (2333096)
GO:0050750low-density lipoprotein receptor bindingMolecular FunctionISS
GO:0006810transportBiological ProcessIEA
GO:0007269neurotransmitter secretionBiological ProcessIEA
GO:0007269neurotransmitter secretionBiological ProcessISS
GO:0016079synaptic vesicle exocytosisBiological ProcessTAS (2333096)
GO:0017156calcium ion-dependent exocytosisBiological ProcessTAS (2333096)
Other Database Cross Links
NCBI Entrez Gene:25716
RGD:3803
Ensembl:ENSRNOG00000006426
dbSNP:Syt1