ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

TCF12

Full Name:

transcription factor 12 (HTF4, helix-loop-helix transcription factors 4)

Alias:

HEB|HTF4|HsT17266

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

15q21

Physical Location:

54998124-55368007 on NC_000015.8

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Hs.511504
Note:		"Class II, down-regulated gene"

Dataset Information

Name:		16292326
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
Summary:		In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05.

Gene Information

Original ID1:

TCF12

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005622	intracellular	Cellular Component	IDA (11256614)
GO:0005634	nucleus	Cellular Component	IEA
GO:0003677	DNA binding	Molecular Function	IEA
GO:0003702	RNA polymerase II transcription factor activity	Molecular Function	TAS (8163514)
GO:0030528	transcription regulator activity	Molecular Function	IEA
GO:0007517	muscle development	Biological Process	TAS (1312219)
GO:0007275	multicellular organismal development	Biological Process	IEA
GO:0006955	immune response	Biological Process	TAS (1312219)
GO:0006357	regulation of transcription from RNA polymerase II promoter	Biological Process	TAS (8163514)
GO:0045449	regulation of transcription	Biological Process	IEA