ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Rhou

Full Name:

ras homolog gene family, member U

Alias:

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

8 E2

Physical Location:

126177828-126187779 on NC_000074.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 58480 Symbol (Name): RHOU (ras homolog gene family, member U)

Ortholog Status:

The human GeneID 58480 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Rhou
Original ID2:		AV246963

Gene Information

Original ID1:		Rhou
Original ID2:		AW121294

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_133955.4	NP_598716.1	NC_000074.5 range: 126177828..126187779

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005622	intracellular	Cellular Component	IEA
GO:0016020	membrane	Cellular Component	IEA
GO:0030054	cell junction	Cellular Component	IEA
GO:0042995	cell projection	Cellular Component	IEA
GO:0005794	Golgi apparatus	Cellular Component	IEA
GO:0005575	cellular_component	Cellular Component	ND
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0005525	GTP binding	Molecular Function	RCA (12466851)
GO:0003924	GTPase activity	Molecular Function	IMP (11459829)
GO:0000287	magnesium ion binding	Molecular Function	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0030036	actin cytoskeleton organization and biogenesis	Biological Process	IDA (11459829)
GO:0016601	Rac protein signal transduction	Biological Process	IDA (11459829)
GO:0008360	regulation of cell shape	Biological Process	IDA (11459829)
GO:0007264	small GTPase mediated signal transduction	Biological Process	RCA (12466851)
GO:0000082	G1/S transition of mitotic cell cycle	Biological Process	IDA (11459829)