ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

TFAP2B

Full Name:

transcription factor AP-2 beta (activating enhancer binding protein 2 beta)

Alias:

AP-2B|AP2-B|MGC21381

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

6p12

Physical Location:

50894397-50923284 on NC_000006.10

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

AL049693

Dataset Information

Name:		12065639
Method:		Microarray
Tissue:		Frontal and motor cortices
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Mayfield et al. J Neurochem. (2002) Patterns of gene expression are altered in the frontal and motor cortices of human alcoholics. PubMed
Summary:		We used cDNA microarrays to analyze expression of approximately 10 000 genes in the frontal and motor cortices of three groups of chronic alcoholic and matched control cases. Fluorescent intensity ratios of 1.4-fold or greater in either direction (representing the 99% confidence interval) were used to indicate differentially expressed genes.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_003221.3	NP_003212.2	NC_000006.10 range: 50894397..50923284

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	IC (12169688)
GO:0003700	transcription factor activity	Molecular Function	IDA (12169688)
GO:0003713	transcription coactivator activity	Molecular Function	TAS (7555706)
GO:0043565	sequence-specific DNA binding	Molecular Function	IDA (12169688)
GO:0046983	protein dimerization activity	Molecular Function	IDA (12072434)
GO:0006350	transcription	Biological Process	IEA
GO:0006357	regulation of transcription from RNA polymerase II promoter	Biological Process	TAS (7555706)
GO:0007399	nervous system development	Biological Process	TAS (7555706)
GO:0045817	positive regulation of transcription from RNA polymerase II promoter, global	Biological Process	IDA (12169688)