ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

7042

Symbol:

TGFB2

Full Name:

transforming growth factor, beta 2

Alias:

MGC116892|TGF-beta2

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

1q41

Physical Location:

216586490-216681595 on NC_000001.9

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 21808 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Hs.133379
Note:		"Class II, down-regulated gene"

Dataset Information

Name:		16292326
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
Summary:		In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_003238.1	NP_003229.1	NC_000001.9 range: 216586490..216681595

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005576	extracellular region	Cellular Component	IDA (16227582)
GO:0031093	platelet alpha granule lumen	Cellular Component	EXP (3457014)
GO:0043025	cell soma	Cellular Component	ISS
GO:0030424	axon	Cellular Component	ISS
GO:0005576	extracellular region	Cellular Component	TAS (2119582)
GO:0005576	extracellular region	Cellular Component	EXP (3457014)
GO:0042803	protein homodimerization activity	Molecular Function	IDA (2119582)
GO:0046982	protein heterodimerization activity	Molecular Function	TAS (9611771)
GO:0008083	growth factor activity	Molecular Function	IEA
GO:0005160	transforming growth factor beta receptor binding	Molecular Function	IEA
GO:0005160	transforming growth factor beta receptor binding	Molecular Function	IDA (16227582)
GO:0001540	beta-amyloid binding	Molecular Function	IDA (16227582)
GO:0005125	cytokine activity	Molecular Function	TAS (9611771)
GO:0060038	cardiac muscle cell proliferation	Biological Process	IDA (15896309)
GO:0051891	positive regulation of cardioblast differentiation	Biological Process	IDA (15896309)
GO:0043525	positive regulation of neuron apoptosis	Biological Process	IDA (16227582)
GO:0051795	positive regulation of catagen	Biological Process	IDA (15955085)
GO:0045787	positive regulation of cell cycle	Biological Process	ISS
GO:0045823	positive regulation of heart contraction	Biological Process	IDA (15896309)
GO:0050778	positive regulation of immune response	Biological Process	ISS
GO:0048103	somatic stem cell division	Biological Process	ISS
GO:0048666	neuron development	Biological Process	ISS
GO:0048699	generation of neurons	Biological Process	TAS (15944186)
GO:0050680	negative regulation of epithelial cell proliferation	Biological Process	IMP (16943770)
GO:0050777	negative regulation of immune response	Biological Process	TAS (9611771)
GO:0042416	dopamine biosynthetic process	Biological Process	ISS
GO:0042060	wound healing	Biological Process	ISS
GO:0032909	regulation of transforming growth factor-beta2 production	Biological Process	IMP (12411310)
GO:0001654	eye development	Biological Process	IDA (15944186)
GO:0001666	response to hypoxia	Biological Process	IMP (12411310)
GO:0001837	epithelial to mesenchymal transition	Biological Process	TAS (14679171)
GO:0000902	cell morphogenesis	Biological Process	IDA (15896309)
GO:0007267	cell-cell signaling	Biological Process	TAS (3322813)
GO:0008219	cell death	Biological Process	IDA (16227582)
GO:0008284	positive regulation of cell proliferation	Biological Process	IDA (15896309)
GO:0009790	embryonic development	Biological Process	TAS (2119582)
GO:0016049	cell growth	Biological Process	IEA
GO:0030097	hemopoiesis	Biological Process	ISS
GO:0030307	positive regulation of cell growth	Biological Process	IDA (15896309)
GO:0030593	neutrophil chemotaxis	Biological Process	ISS
GO:0030593	neutrophil chemotaxis	Biological Process	TAS (9611771)
GO:0031069	hair follicle morphogenesis	Biological Process	ISS
GO:0001525	angiogenesis	Biological Process	TAS (9611771)