ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

7046

Symbol:

TGFBR1

Full Name:

transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kDa)

Alias:

AAT5|ACVRLK4|ALK-5|ALK5|LDS1A|LDS2A|SKR4|TGFR-1

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

9q22

Physical Location:

100907232-100956294 on NC_000009.10

Gene Type:

protein-coding

Orthologs:

This gene has Rat: 29591 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

TGFBR1

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_004612.2	NP_004603.1	NC_000009.10 range: 100907232..100956294

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0043235	receptor complex	Cellular Component	IDA (8774881)
GO:0016020	membrane	Cellular Component	IEA
GO:0005886	plasma membrane	Cellular Component	EXP (9865696\|11100470)
GO:0005887	integral to plasma membrane	Cellular Component	TAS (8242743)
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0046332	SMAD binding	Molecular Function	IDA (12065756)
GO:0030145	manganese ion binding	Molecular Function	IEA
GO:0016740	transferase activity	Molecular Function	IEA
GO:0050431	transforming growth factor beta binding	Molecular Function	IDA (14633705)
GO:0005025	transforming growth factor beta receptor activity, type I	Molecular Function	TAS (8242743)
GO:0000287	magnesium ion binding	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0004872	receptor activity	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IDA (12065756)
GO:0005024	transforming growth factor beta receptor activity	Molecular Function	IEA
GO:0045449	regulation of transcription	Biological Process	IMP (15702480)
GO:0045449	regulation of transcription	Biological Process	IDA (14517293)
GO:0006468	protein amino acid phosphorylation	Biological Process	IDA (12065756)
GO:0008284	positive regulation of cell proliferation	Biological Process	IMP (14633705)
GO:0007181	transforming growth factor beta receptor complex assembly	Biological Process	TAS (8242743)
GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway	Biological Process	IEA
GO:0006468	protein amino acid phosphorylation	Biological Process	IEA
GO:0007165	signal transduction	Biological Process	IDA (14633705)