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Gene Information
Gene ID:29591
Symbol:Tgfbr1
Full Name:transforming growth factor, beta receptor 1
Alias:MGC93659
Organism:Rattus norvegicus (Rat)
Chromosome:5
Genetic Location:5q22
Physical Location:63976867-64034057 on NC_005104.2
Gene Type:protein-coding
Human Ortholog:GeneID: 7046    Symbol (Name): TGFBR1 (transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kDa))
Ortholog Status:The human GeneID 7046 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Tgfbr1
Fold Change:-1.18
P Value:0.004
Note:Differential expression between ethanol and water groups in amygdala
Dataset Information
Name:18405950
Method:Microarray
Tissue:Nucleus accumbens and amygdala
Phenotype:Ethanol self-administration, alcohol-preferring
Publication:Rodd et al. Pharmacol Biochem Behav. (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. PubMed
Summary:The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. For the ACB, there were 513 significant differences at the p < 0.01 level in named genes: 55 between SAC and water; 215 between EtOH and water, and 243 between EtOH and SAC. In the case of the AMYG (p < 0.01), there were 48 between SAC and water, 23 between EtOH and water, and 63 between EtOH and SAC group.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_012775.2NP_036907.2NC_005104.2 range: 63976867..64034057
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0016324apical plasma membraneCellular ComponentIDA (10590020)
GO:0016020membraneCellular ComponentIEA
GO:0043235receptor complexCellular ComponentISS
GO:0016021integral to membraneCellular ComponentIEA
GO:0016323basolateral plasma membraneCellular ComponentIDA (10590020)
GO:0005524ATP bindingMolecular FunctionIEA
GO:0005524ATP bindingMolecular FunctionISS
GO:0050431transforming growth factor beta bindingMolecular FunctionISS
GO:0000166nucleotide bindingMolecular FunctionIEA
GO:0046332SMAD bindingMolecular FunctionISS
GO:0046982protein heterodimerization activityMolecular FunctionIMP (8272871)
GO:0005515protein bindingMolecular FunctionISS
GO:0005515protein bindingMolecular FunctionIEA
GO:0005025transforming growth factor beta receptor activity, type IMolecular FunctionIMP (8272871)
GO:0000287magnesium ion bindingMolecular FunctionIEA
GO:0030145manganese ion bindingMolecular FunctionIEA
GO:0050431transforming growth factor beta bindingMolecular FunctionIDA (8272871)
GO:0016740transferase activityMolecular FunctionIEA
GO:0004674protein serine/threonine kinase activityMolecular FunctionIMP (8272871)
GO:0004872receptor activityMolecular FunctionIEA
GO:0005024transforming growth factor beta receptor activityMolecular FunctionIEA
GO:0005024transforming growth factor beta receptor activityMolecular FunctionISS
GO:0046777protein amino acid autophosphorylationBiological ProcessIMP (8272871)
GO:0043627response to estrogen stimulusBiological ProcessIDA (12097811)
GO:0048538thymus developmentBiological ProcessIEA
GO:0045449regulation of transcriptionBiological ProcessISS
GO:0048663neuron fate commitmentBiological ProcessIEA
GO:0060037pharyngeal system developmentBiological ProcessISS
GO:0060037pharyngeal system developmentBiological ProcessIEA
GO:0060021palate developmentBiological ProcessISS
GO:0060021palate developmentBiological ProcessIEA
GO:0060017parathyroid gland developmentBiological ProcessISS
GO:0060017parathyroid gland developmentBiological ProcessIEA
GO:0048538thymus developmentBiological ProcessISS
GO:0048844artery morphogenesisBiological ProcessISS
GO:0048844artery morphogenesisBiological ProcessIEA
GO:0048705skeletal morphogenesisBiological ProcessISS
GO:0048705skeletal morphogenesisBiological ProcessIEA
GO:0048663neuron fate commitmentBiological ProcessISS
GO:0043066negative regulation of apoptosisBiological ProcessISS
GO:0043066negative regulation of apoptosisBiological ProcessIEA
GO:0007179transforming growth factor beta receptor signaling pathwayBiological ProcessIMP (8272871)
GO:0007179transforming growth factor beta receptor signaling pathwayBiological ProcessIEA
GO:0007165signal transductionBiological ProcessISS
GO:0006468protein amino acid phosphorylationBiological ProcessISS
GO:0006468protein amino acid phosphorylationBiological ProcessIEA
GO:0001822kidney developmentBiological ProcessISS
GO:0001822kidney developmentBiological ProcessIEA
GO:0001701in utero embryonic developmentBiological ProcessISS
GO:0001701in utero embryonic developmentBiological ProcessIEA
GO:0007179transforming growth factor beta receptor signaling pathwayBiological ProcessISS
GO:0007507heart developmentBiological ProcessIEA
GO:0007507heart developmentBiological ProcessISS
GO:0030199collagen fibril organizationBiological ProcessISS
GO:0030199collagen fibril organizationBiological ProcessIEA
GO:0008284positive regulation of cell proliferationBiological ProcessISS
GO:0009952anterior/posterior pattern formationBiological ProcessISS
GO:0009952anterior/posterior pattern formationBiological ProcessIEA
GO:0009790embryonic developmentBiological ProcessISS
GO:0009790embryonic developmentBiological ProcessIEA
GO:0008354germ cell migrationBiological ProcessISS
GO:0008354germ cell migrationBiological ProcessIEA
GO:0001501skeletal developmentBiological ProcessISS
Other Database Cross Links
NCBI Entrez Gene:29591
RGD:3852
Ensembl:ENSRNOG00000007036
dbSNP:Tgfbr1