ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

THRB

Full Name:

thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)

Alias:

ERBA-BETA|ERBA2|GRTH|MGC126109|MGC126110|NR1A2|THR1|THRB1|THRB2

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

3p24.2

Physical Location:

24134708-24511316 on NC_000003.10, complement

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

M26747

Dataset Information

Name:		12065639
Method:		Microarray
Tissue:		Frontal and motor cortices
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Mayfield et al. J Neurochem. (2002) Patterns of gene expression are altered in the frontal and motor cortices of human alcoholics. PubMed
Summary:		We used cDNA microarrays to analyze expression of approximately 10 000 genes in the frontal and motor cortices of three groups of chronic alcoholic and matched control cases. Fluorescent intensity ratios of 1.4-fold or greater in either direction (representing the 99% confidence interval) were used to indicate differentially expressed genes.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_000461.4	NP_000452.2	NC_000003.10 range: 24134708..24511316, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	TAS (1618799)
GO:0043565	sequence-specific DNA binding	Molecular Function	IEA
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0003700	transcription factor activity	Molecular Function	NAS (1618799)
GO:0005515	protein binding	Molecular Function	IPI (7870181\|15100213\|15625236)
GO:0004887	thyroid hormone receptor activity	Molecular Function	TAS (1618799)
GO:0003714	transcription corepressor activity	Molecular Function	TAS (1618799)
GO:0003707	steroid hormone receptor activity	Molecular Function	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	IEA
GO:0007605	sensory perception of sound	Biological Process	IEA