ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

TIMP1

Full Name:

TIMP metallopeptidase inhibitor 1

Alias:

CLGI|EPA|EPO|FLJ90373|HCI|TIMP

Organism:

Homo sapiens (Human)

Chromosome:

X

Genetic Location:

Xp11.3-p11.23

Physical Location:

47326633-47331133 on NC_000023.9

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

AI831659

Dataset Information

Name:		12065639
Method:		Microarray
Tissue:		Frontal and motor cortices
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Mayfield et al. J Neurochem. (2002) Patterns of gene expression are altered in the frontal and motor cortices of human alcoholics. PubMed
Summary:		We used cDNA microarrays to analyze expression of approximately 10 000 genes in the frontal and motor cortices of three groups of chronic alcoholic and matched control cases. Fluorescent intensity ratios of 1.4-fold or greater in either direction (representing the 99% confidence interval) were used to indicate differentially expressed genes.

Gene Information

Original ID1:

TIMP1

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_003254.2	NP_003245.1	NC_000023.9 range: 47326633..47331133

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005576	extracellular region	Cellular Component	IEA
GO:0005576	extracellular region	Cellular Component	NAS (1653055)
GO:0005578	proteinaceous extracellular matrix	Cellular Component	IEA
GO:0004857	enzyme inhibitor activity	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (2251898)
GO:0008191	metalloendopeptidase inhibitor activity	Molecular Function	IDA (12714508)
GO:0008191	metalloendopeptidase inhibitor activity	Molecular Function	IEA
GO:0043249	erythrocyte maturation	Biological Process	IEA
GO:0008284	positive regulation of cell proliferation	Biological Process	TAS (3839290)
GO:0007275	multicellular organismal development	Biological Process	NR
GO:0051045	negative regulation of membrane protein ectodomain proteolysis	Biological Process	IDA (12714508)

Other Database Cross Links

NCBI Entrez Gene:

HGNC:

Ensembl:

ENSG00000102265

MIM:

HPRD:

HuGE Navigator:

dbSNP:

GeneCard:

AceView: