ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

TIMP2

Full Name:

TIMP metallopeptidase inhibitor 2

Alias:

CSC-21K

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

17q25

Physical Location:

74360653-74433066 on NC_000017.9, complement

Gene Type:

protein-coding

Orthologs:

This gene has Fly: 41248 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

TIMP2

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene Information

Dataset Information

Name:		15816859
Method:		Microarray
Tissue:		Prefrontal cortex and nucleus accumbens
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Flatscher-Bader et al. J Neurochem.(2005) Alcohol-responsive genes in the frontal cortex and nucleus accumbens of human alcoholics. PubMed
Summary:		Genes with a mean fold change > 1.5 or < 0.7 were selected and annotated. Values are taken from microarray analysis and represent mean ratios of alcoholic cases compared with matched control cases(n = 6). P values were from t-test.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_003255.4	NP_003246.1	NC_000017.9 range: 74360653..74433066, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005576	extracellular region	Cellular Component	IEA
GO:0005578	proteinaceous extracellular matrix	Cellular Component	IEA
GO:0004857	enzyme inhibitor activity	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (17353931)
GO:0008191	metalloendopeptidase inhibitor activity	Molecular Function	TAS (8810321)