Logo
Home Search BLAST Integration Document Link Support Citation

Gene Information
Gene ID:41248
Symbol:Timp
Alias:CG6281|DTIMP
Organism:Drosophila melanogaster (Fly)
Chromosome:3R
Genetic Location:86A1-86A1
Physical Location:6029596-6038709 on NT_033777.2, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 7077    Symbol (Name): TIMP2 (TIMP metallopeptidase inhibitor 2)
Ortholog Status:The human GeneID 7077 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Timp
P Value:4.52E-02
Note:Slow up-regulation
Dataset Information
Name:17054780
Method:Microarray
Phenotype:Ethanol response
Publication:Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_079577.3NP_524301.2NT_033777.2 range: 6029596..6038709, complement
NM_169336.2NP_731461.1NT_033777.2 range: 6029596..6038709, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005576extracellular regionCellular ComponentISS (10198170)
GO:0005578proteinaceous extracellular matrixCellular ComponentIEA
GO:0030425dendriteCellular ComponentIMP (16210248)
GO:0005515protein bindingMolecular FunctionIEA
GO:0008191metalloendopeptidase inhibitor activityMolecular FunctionIDA (14567681)
GO:0008191metalloendopeptidase inhibitor activityMolecular FunctionISS (10198170)
GO:0008191metalloendopeptidase inhibitor activityMolecular FunctionNAS
Other Database Cross Links
NCBI Entrez Gene:41248
FLYBASE:FBgn0025879