ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Timp

Alias:

CG6281|DTIMP

Organism:

Drosophila melanogaster (Fly)

Chromosome:

Genetic Location:

86A1-86A1

Physical Location:

6029596-6038709 on NT_033777.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 7077 Symbol (Name): TIMP2 (TIMP metallopeptidase inhibitor 2)

Ortholog Status:

The human GeneID 7077 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Dataset Information

Name:		17054780
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:		We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005576	extracellular region	Cellular Component	ISS (10198170)
GO:0005578	proteinaceous extracellular matrix	Cellular Component	IEA
GO:0030425	dendrite	Cellular Component	IMP (16210248)
GO:0005515	protein binding	Molecular Function	IEA
GO:0008191	metalloendopeptidase inhibitor activity	Molecular Function	IDA (14567681)
GO:0008191	metalloendopeptidase inhibitor activity	Molecular Function	ISS (10198170)
GO:0008191	metalloendopeptidase inhibitor activity	Molecular Function	NAS