ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

TIMP3

Full Name:

TIMP metallopeptidase inhibitor 3 (Sorsby fundus dystrophy, pseudoinflammatory)

Alias:

HSMRK222|K222|K222TA2|SFD

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

22q12.1-q13.2|22q12.3

Physical Location:

31526801-31589027 on NC_000022.9

Gene Type:

protein-coding

Orthologs:

This gene has Rat: 25358 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Dataset Information

Name:		15816859
Method:		Microarray
Tissue:		Prefrontal cortex and nucleus accumbens
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Flatscher-Bader et al. J Neurochem.(2005) Alcohol-responsive genes in the frontal cortex and nucleus accumbens of human alcoholics. PubMed
Summary:		Genes with a mean fold change > 1.5 or < 0.7 were selected and annotated. Values are taken from microarray analysis and represent mean ratios of alcoholic cases compared with matched control cases(n = 6). P values were from t-test.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_000362.4	NP_000353.1	NC_000022.9 range: 31526801..31589027

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005578	proteinaceous extracellular matrix	Cellular Component	NAS (7925969)
GO:0005576	extracellular region	Cellular Component	IEA
GO:0005578	proteinaceous extracellular matrix	Cellular Component	IEA
GO:0008191	metalloendopeptidase inhibitor activity	Molecular Function	IEA
GO:0003674	molecular_function	Molecular Function	ND
GO:0005515	protein binding	Molecular Function	IEA
GO:0004857	enzyme inhibitor activity	Molecular Function	IEA
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	Biological Process	NAS (15609325)
GO:0007601	visual perception	Biological Process	IEA
GO:0008624	induction of apoptosis by extracellular signals	Biological Process	NAS (7925969)
GO:0050896	response to stimulus	Biological Process	IEA