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Gene Information
Gene ID:25358
Full Name:tissue inhibitor of metalloproteinase 3
Organism:Rattus norvegicus (Rat)
Genetic Location:7q13
Physical Location:19677143-19727071 on NC_005106.2, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 7078    Symbol (Name): TIMP3 (TIMP metallopeptidase inhibitor 3 (Sorsby fundus dystrophy, pseudoinflammatory))
Ortholog Status:The human GeneID 7078 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:25358
Fold Change:0.484
P Value:0.0075
Note:Fold change is average ratio of AA to ANA.
Dataset Information
Tissue:Frontal cortex
Phenotype:Alcohol-preferring, alcohol-nonpreferring
Publication:Worst et al. J Neurosci Res. (2005) Transcriptome analysis of frontal cortex in alcohol-preferring and nonpreferring rats. PubMed
Summary:DNA macroarrays were used to probe for differences in normative cortical gene expression between rat strains genetically selected for alcohol selfadministration preference, AA (Alko, alcohol) and P (Indiana, preferring), or avoidance, ANA (Alko, nonalcohol) and NP (Indiana, nonpreferring). Among 1,176 genes studied, six demonstrated confirmable, differential expression following comparison of ethanol-naive AA and ANA rats.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_012886.2NP_037018.2NC_005106.2 range: 19677143..19727071, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005575cellular_componentCellular ComponentND
GO:0005576extracellular regionCellular ComponentIEA
GO:0005578proteinaceous extracellular matrixCellular ComponentIEA
GO:0005604basement membraneCellular ComponentIEA
GO:0005604basement membraneCellular ComponentISS
GO:0005737cytoplasmCellular ComponentIDA (17551674)
GO:0004857enzyme inhibitor activityMolecular FunctionIEA
GO:0008191metalloendopeptidase inhibitor activityMolecular FunctionTAS (11827969)
GO:0008191metalloendopeptidase inhibitor activityMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionIEA
GO:0007417central nervous system developmentBiological ProcessIEP (11044612)
GO:0045861negative regulation of proteolysisBiological ProcessIMP (17532789)
GO:0043627response to estrogen stimulusBiological ProcessIEP (15866537)
GO:0043200response to amino acid stimulusBiological ProcessIEP (17083784)
GO:0042246tissue regenerationBiological ProcessIEP (16683235)
GO:0014070response to organic cyclic substanceBiological ProcessIEP (15866537)
GO:0010033response to organic substanceBiological ProcessIEP (17555880)
GO:0009725response to hormone stimulusBiological ProcessIEP (17275272)
GO:0009612response to mechanical stimulusBiological ProcessIEP (17717962)
GO:0006917induction of apoptosisBiological ProcessTAS (11827969)
GO:0007568agingBiological ProcessIEP (18278151)
GO:0051593response to folic acidBiological ProcessIEP (18156304)
Other Database Cross Links
NCBI Entrez Gene:25358