| Gene Information |
| Gene ID: | | 7080 |
| Symbol: | | NKX2-1 |
| Full Name: | | NK2 homeobox 1 |
| Alias: | | BCH|BHC|NK-2|NKX2.1|NKX2A|TEBP|TITF1|TTF-1|TTF1 |
| Organism: | | Homo sapiens (Human) |
| Chromosome: | | 14 |
| Genetic Location: | | 14q13 |
| Physical Location: | | 36055352-36059166 on NC_000014.7, complement |
| Gene Type: | | protein-coding |
| Orthologs: | | This gene has no orthologs in other dataset(s). |
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| Gene in Ethanol Study Datasets |
| Gene Information | | | Dataset Information | | Name: | | 12065639 | | Method: | | Microarray | | Tissue: | | Frontal and motor cortices | | Phenotype: | | Alcohol dependence (AD)/Alcohol abuse/Alcoholism | | Publication: | | Mayfield et al. J Neurochem. (2002) Patterns of gene expression are altered in the frontal and motor cortices of human alcoholics. PubMed | | Summary: | | We used cDNA microarrays to analyze expression of approximately 10 000 genes in the frontal and motor cortices of three groups of chronic alcoholic and matched control cases. Fluorescent intensity ratios of 1.4-fold or greater in either direction (representing the 99% confidence interval) were used to indicate differentially expressed genes. |
| | Gene Information | | | Dataset Information | | Name: | | Literature Search | | Method: | | Literature search | | Summary: | | We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive. |
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| Gene Refseq Sequence Annotation |
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| Gene Ontology (GO) Annotation |
| GO ID | GO Term | Category | Evidence (PubMed) | |
| GO:0005634 | nucleus | Cellular Component | NAS | |
| GO:0005654 | nucleoplasm | Cellular Component | ISS | |
| GO:0003700 | transcription factor activity | Molecular Function | IEA | |
| GO:0005515 | protein binding | Molecular Function | ISS | |
| GO:0016563 | transcription activator activity | Molecular Function | ISS | |
| GO:0016563 | transcription activator activity | Molecular Function | NAS (7711080|7713914) | |
| GO:0043565 | sequence-specific DNA binding | Molecular Function | IEA | |
| GO:0045893 | positive regulation of transcription, DNA-dependent | Biological Process | ISS | |
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| Other Database Cross Links |
| NCBI Entrez Gene: | | 7080 |
| HGNC: | | 11825 |
| Ensembl: | | ENSG00000136352 |
| MIM: | | 600635 |
| HPRD: | | 02798 |
| HuGE Navigator: | | 7080 |
| dbSNP: | | NKX2-1 |
| GeneCard: | | NKX2-1 |
| AceView: | | NKX2-1 |
