Home Search BLAST Integration Document Link Support Citation

Gene Information
Gene ID:7080
Full Name:NK2 homeobox 1
Organism:Homo sapiens (Human)
Genetic Location:14q13
Physical Location:36055352-36059166 on NC_000014.7, complement
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:AI695053
Dataset Information
Tissue:Frontal and motor cortices
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Mayfield et al. J Neurochem. (2002) Patterns of gene expression are altered in the frontal and motor cortices of human alcoholics. PubMed
Summary:We used cDNA microarrays to analyze expression of approximately 10 000 genes in the frontal and motor cortices of three groups of chronic alcoholic and matched control cases. Fluorescent intensity ratios of 1.4-fold or greater in either direction (representing the 99% confidence interval) were used to indicate differentially expressed genes.
Gene Information
Original ID1:NKX2-1
Dataset Information
Name:Literature Search
Method:Literature search
Summary:We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_001079668.1NP_001073136.1NC_000014.7 range: 36055352..36059166, complement
NM_003317.3NP_003308.1NC_000014.7 range: 36055352..36059166, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005634nucleusCellular ComponentNAS
GO:0005654nucleoplasmCellular ComponentISS
GO:0003700transcription factor activityMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionISS
GO:0016563transcription activator activityMolecular FunctionISS
GO:0016563transcription activator activityMolecular FunctionNAS (7711080|7713914)
GO:0043565sequence-specific DNA bindingMolecular FunctionIEA
GO:0045893positive regulation of transcription, DNA-dependentBiological ProcessISS
Other Database Cross Links
NCBI Entrez Gene:7080
HuGE Navigator:7080