ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

TOP1

Full Name:

topoisomerase (DNA) I

Alias:

TOPI

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

20q12-q13.1

Physical Location:

39090875-39186540 on NC_000020.9

Gene Type:

protein-coding

Orthologs:

This gene has Fly: 32458 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

TOP1

Dataset Information

Name:		Literature Search
Method:		Literature search
Summary:		We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_003286.2	NP_003277.1	NC_000020.9 range: 39090875..39186540

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005694	chromosome	Cellular Component	IDA (9049244)
GO:0005730	nucleolus	Cellular Component	IDA (9049244)
GO:0005654	nucleoplasm	Cellular Component	IDA (9049244)
GO:0005634	nucleus	Cellular Component	IDA (9049244)
GO:0003682	chromatin binding	Molecular Function	IDA (9049244)
GO:0005515	protein binding	Molecular Function	IPI (10352183)
GO:0003918	DNA topoisomerase (ATP-hydrolyzing) activity	Molecular Function	IEA
GO:0003917	DNA topoisomerase type I activity	Molecular Function	IMP (17355975)
GO:0006265	DNA topological change	Biological Process	IEA
GO:0006268	DNA unwinding during replication	Biological Process	IEA
GO:0012501	programmed cell death	Biological Process	NAS (17172417)
GO:0016310	phosphorylation	Biological Process	NAS (17481653)
GO:0042493	response to drug	Biological Process	IEP (16127745)