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Gene Information
Gene ID:32458
Symbol:Top1
Alias:CG6146|TOP1|TopI|Topo I|TopoI|dTopoI|l(1)G0134|l(1)G0201|l(1)G0229|l(1)G0278|l(1)top1
Organism:Drosophila melanogaster (Fly)
Chromosome:X
Genetic Location:13B6-13B6
Physical Location:15213524-15222061 on NC_004354.3
Gene Type:protein-coding
Human Ortholog:GeneID: 7150    Symbol (Name): TOP1 (topoisomerase (DNA) I)
Ortholog Status:The human GeneID 7150 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Top1
P Value:2.26E-02
Note:Slow up-regulation, have human and mouse orthologs.
Dataset Information
Name:17054780
Method:Microarray
Phenotype:Ethanol response
Publication:Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_001014742.1NP_001014742.1NC_004354.3 range: 15213524..15222061
NM_078606.3NP_511161.2NC_004354.3 range: 15213524..15222061
NM_167435.2NP_727841.1NC_004354.3 range: 15213524..15222061
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005737cytoplasmCellular ComponentIDA (10885744)
GO:0005703polytene chromosome puffCellular ComponentIDA (9632819)
GO:0005665DNA-directed RNA polymerase II, core complexCellular ComponentIDA (9632819)
GO:0005634nucleusCellular ComponentIDA (6294622|9632819|10885744)
GO:0003917DNA topoisomerase type I activityMolecular FunctionNAS
GO:0003918DNA topoisomerase (ATP-hydrolyzing) activityMolecular FunctionIEA
GO:0003917DNA topoisomerase type I activityMolecular FunctionISS
GO:0003917DNA topoisomerase type I activityMolecular FunctionIDA (6294622)
GO:0003916DNA topoisomerase activityMolecular FunctionIDA (9632819)
GO:0030261chromosome condensationBiological ProcessIMP (10885744)
GO:0009790embryonic developmentBiological ProcessIMP (10885744)
GO:0008283cell proliferationBiological ProcessIMP (10885744)
GO:0007275multicellular organismal developmentBiological ProcessIMP (8393572)
GO:0007059chromosome segregationBiological ProcessIMP (10885744)
GO:0006268DNA unwinding during replicationBiological ProcessIEA
GO:0006265DNA topological changeBiological ProcessIDA (6294622)
GO:0002168instar larval developmentBiological ProcessIMP (10885744)
GO:0048477oogenesisBiological ProcessIMP (10885744)
Other Database Cross Links
NCBI Entrez Gene:32458
FLYBASE:FBgn0004924