ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Top1

Alias:

CG6146|TOP1|TopI|Topo I|TopoI|dTopoI|l(1)G0134|l(1)G0201|l(1)G0229|l(1)G0278|l(1)top1

Organism:

Drosophila melanogaster (Fly)

Chromosome:

Genetic Location:

13B6-13B6

Physical Location:

15213524-15222061 on NC_004354.3

Gene Type:

protein-coding

Human Ortholog:

GeneID: 7150 Symbol (Name): TOP1 (topoisomerase (DNA) I)

Ortholog Status:

The human GeneID 7150 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Top1
P Value:		2.26E-02
Note:		Slow up-regulation, have human and mouse orthologs.

Dataset Information

Name:		17054780
Method:		Microarray
Phenotype:		Ethanol response
Publication:		Morozova et al. Genome Biol. (2006) Transcriptional response to alcohol exposure in Drosophila melanogaster. PubMed
Summary:		We assessed whole-genome transcriptional responses following alcohol exposure and demonstrate immediate down-regulation of genes affecting olfaction, rapid upregulation of biotransformation enzymes and, concomitant with development of tolerance, altered transcription of transcriptional regulators, proteases and metabolic enzymes, including biotransformation enzymes and enzymes associated with fatty acid biosynthesis. Functional tests of P-element disrupted alleles corresponding to genes with altered transcription implicated 75% of these in the response to alcohol, two-thirds of which have human orthologues. We performed analysis of variance to identify probe sets with significant differences in expression between the three treatments, and a false positive discovery rate of q < 0.05 to account for multiple tests.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005737	cytoplasm	Cellular Component	IDA (10885744)
GO:0005703	polytene chromosome puff	Cellular Component	IDA (9632819)
GO:0005665	DNA-directed RNA polymerase II, core complex	Cellular Component	IDA (9632819)
GO:0005634	nucleus	Cellular Component	IDA (6294622\|9632819\|10885744)
GO:0003917	DNA topoisomerase type I activity	Molecular Function	NAS
GO:0003918	DNA topoisomerase (ATP-hydrolyzing) activity	Molecular Function	IEA
GO:0003917	DNA topoisomerase type I activity	Molecular Function	ISS
GO:0003917	DNA topoisomerase type I activity	Molecular Function	IDA (6294622)
GO:0003916	DNA topoisomerase activity	Molecular Function	IDA (9632819)
GO:0030261	chromosome condensation	Biological Process	IMP (10885744)
GO:0009790	embryonic development	Biological Process	IMP (10885744)
GO:0008283	cell proliferation	Biological Process	IMP (10885744)
GO:0007275	multicellular organismal development	Biological Process	IMP (8393572)
GO:0007059	chromosome segregation	Biological Process	IMP (10885744)
GO:0006268	DNA unwinding during replication	Biological Process	IEA
GO:0006265	DNA topological change	Biological Process	IDA (6294622)
GO:0002168	instar larval development	Biological Process	IMP (10885744)
GO:0048477	oogenesis	Biological Process	IMP (10885744)