ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Sfpq

Full Name:

splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated)

Alias:

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

4 D2.2|4 57.6 cM

Physical Location:

126698578-126708039 on NC_000070.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 6421 Symbol (Name): SFPQ (splicing factor proline/glutamine-rich (polypyrimidine tract binding protein associated))

Ortholog Status:

The human GeneID 6421 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		AW060546
Fold Change:		-1.1, NC, -1.9, -1.6
Note:		4 fold changes are from C57BL/6J trial 1, C57BL/6J trial 2, DBA/2J trial 1, DBA/2J trial 2

Dataset Information

Name:		15002731
Method:		Microarray
Tissue:		Whole brain
Phenotype:		Acute ethanol response
Publication:		Treadwell et al. Neurochem Res. (2004) Microarray analysis of mouse brain gene expression following acute ethanol treatment. PubMed
Summary:		We have analyzed the expression of approximately 24,000 genes using oligonucleotide microarrays to examine the brain expression profiles in two strains of inbred mice, C57BL/6J and DBA/2J, following exposure to an acute dose of ethanol. Our screen identified 61 genes responding to the ethanol treatment beyond a 1.5-fold threshold, with 46 genes altered in both mouse strains and 15 altered in only one strain.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_023603.2	NP_076092.1	NC_000070.5 range: 126698578..126708039

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005575	cellular_component	Cellular Component	ND
GO:0005634	nucleus	Cellular Component	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0003676	nucleic acid binding	Molecular Function	IEA
GO:0003677	DNA binding	Molecular Function	IEA
GO:0003723	RNA binding	Molecular Function	IEA
GO:0008150	biological_process	Biological Process	ND
GO:0006974	response to DNA damage stimulus	Biological Process	IEA
GO:0006397	mRNA processing	Biological Process	IEA
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	IEA
GO:0006350	transcription	Biological Process	IEA
GO:0006281	DNA repair	Biological Process	IEA
GO:0008380	RNA splicing	Biological Process	IEA