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Gene Information
Gene ID:6421
Symbol:SFPQ
Full Name:splicing factor proline/glutamine-rich (polypyrimidine tract binding protein associated)
Alias:POMP100|PSF
Organism:Homo sapiens (Human)
Chromosome:1
Genetic Location:1p34.3
Physical Location:35421787-35431321 on NC_000001.9, complement
Gene Type:protein-coding
Orthologs:This gene has Mouse: 71514 ortholog(s) in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Hs.355934
Note:"Class II, down-regulated gene"
Dataset Information
Name:16292326
Method:Microarray
Tissue:Frontal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
Summary:In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_005066.1NP_005057.1NC_000001.9 range: 35421787..35431321, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0016363nuclear matrixCellular ComponentIEA
GO:0005634nucleusCellular ComponentIEA
GO:0000166nucleotide bindingMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionIPI (9848648|10653975|11259580|15231747)
GO:0003723RNA bindingMolecular FunctionIEA
GO:0003677DNA bindingMolecular FunctionIEA
GO:0006281DNA repairBiological ProcessIEA
GO:0006350transcriptionBiological ProcessIEA
GO:0006355regulation of transcription, DNA-dependentBiological ProcessIEA
GO:0006397mRNA processingBiological ProcessTAS (8449401)
GO:0008380RNA splicingBiological ProcessTAS (8449401)
GO:0006310DNA recombinationBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:6421
HGNC:10774
Ensembl:ENSG00000116560
MIM:605199
HPRD:07284
HuGE Navigator:6421
dbSNP:SFPQ
GeneCard:SFPQ
AceView:SFPQ