ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

SFPQ

Full Name:

splicing factor proline/glutamine-rich (polypyrimidine tract binding protein associated)

Alias:

POMP100|PSF

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

1p34.3

Physical Location:

35421787-35431321 on NC_000001.9, complement

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 71514 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Hs.355934
Note:		"Class II, down-regulated gene"

Dataset Information

Name:		16292326
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
Summary:		In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_005066.1	NP_005057.1	NC_000001.9 range: 35421787..35431321, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016363	nuclear matrix	Cellular Component	IEA
GO:0005634	nucleus	Cellular Component	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (9848648\|10653975\|11259580\|15231747)
GO:0003723	RNA binding	Molecular Function	IEA
GO:0003677	DNA binding	Molecular Function	IEA
GO:0006281	DNA repair	Biological Process	IEA
GO:0006350	transcription	Biological Process	IEA
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	IEA
GO:0006397	mRNA processing	Biological Process	TAS (8449401)
GO:0008380	RNA splicing	Biological Process	TAS (8449401)
GO:0006310	DNA recombination	Biological Process	IEA