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Gene Information
Gene ID:7167
Full Name:triosephosphate isomerase 1
Organism:Homo sapiens (Human)
Genetic Location:12p13
Physical Location:6846966-6850252 on NC_000012.10
Gene Type:protein-coding
Orthologs:This gene has no orthologs in other dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:Hs.524219
Note:"Class II, up-regulated gene"
Dataset Information
Tissue:Frontal cortex
Phenotype:Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:Liu et al. Neuropsychopharmacology. (2006) Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. PubMed
Summary:In the present study, microarray analysis (approximately 47,000 elements) was performed on the superior frontal cortex of 27 individual human cases (14 well characterized alcoholics and 13 matched controls). A classification system was developed in which differentially expressed genes were divided into two classes. Class I genes were qualitatively different, that is, they were predominantly detected in one group but not the other. Multiple criteria were used to define Class II genes. First, only the genes detected on over 80% of the arrays in both groups. Class II were then defined as those consistently detected in both groups having absolute PLS loadings scores of >2.0 and t- probabilities of <0.05.
Gene Information
Original ID1:TPI1
Dataset Information
Name:Literature Search
Method:Literature search
Summary:We search all human protein coding gene names and the keywords Alcohol or Ethanol or Alcoholism in the title or abstract of all PUBMED publications. For those gene name less than 3 characters or search result hits more than 100, we use the full name to search again and manually check the results to reduce false positive.
Linkage Dataset
MarkerLODP valueLocation (bp)
D12S99  5434815
Phenotype:Alcoholism phenotype along with age, gender, and P300 or constraint
Publication:Hill et al. Am J Med Genet B Neuropsychiatr Genet. (2004) A genome wide search for alcoholism susceptibility genes. PubMed
Summary:A total of 360 markers for 22 autosomes were spaced at an average distance of 9.4cMand genotyping performed for 330 members of these multiplex families. Extensive clinical data, personality variation, and event-related potential characteristics were available for reducing heterogeneity and detecting robust linkage signals. Multipoint linkage analysis using different analytic strategies give strong support for loci on chromosomes 1, 2, 6, 7, 10, 12, 14, 16, and 17. Thirty five markers with LOD score >2.0 at baseline using the binary alcoholism phenotype along with age, gender, and P300 or constraint (Table III). Here we listed the genes between two near markers or genes near a separate marker (within 2Mb).
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_000365.4NP_000356.1NC_000012.10 range: 6846966..6850252
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005829cytosolCellular ComponentEXP (6434534)
GO:0004807triose-phosphate isomerase activityMolecular FunctionEXP (6434534)
GO:0016853isomerase activityMolecular FunctionIEA
GO:0004807triose-phosphate isomerase activityMolecular FunctionTAS (2579079)
GO:0004807triose-phosphate isomerase activityMolecular FunctionNAS (2876430)
GO:0006094gluconeogenesisBiological ProcessIEA
GO:0006098pentose-phosphate shuntBiological ProcessIEA
GO:0006633fatty acid biosynthetic processBiological ProcessIEA
GO:0008152metabolic processBiological ProcessIEA
GO:0006096glycolysisBiological ProcessIEA
Other Database Cross Links
NCBI Entrez Gene:7167
HuGE Navigator:7167