ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Cul2

Full Name:

cullin 2

Alias:

1300003D18Rik|4932411N15Rik|AI327301|KIAA4106|mKIAA4106

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

18 A1

Physical Location:

3383028-3436371 on NC_000084.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 8453 Symbol (Name): CUL2 (cullin 2)

Ortholog Status:

The human GeneID 8453 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Cul2
Original ID2:		AI854281

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_029402.3	NP_083678.2	NC_000084.5 range: 3383028..3436371

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0031461	cullin-RING ubiquitin ligase complex	Cellular Component	IEA
GO:0005515	protein binding	Molecular Function	IPI (15601820\|17500595)
GO:0031625	ubiquitin protein ligase binding	Molecular Function	IEA
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IEA
GO:0006512	ubiquitin cycle	Biological Process	IEA
GO:0030163	protein catabolic process	Biological Process	IMP (15601820)