| Gene Information | | Original ID1: | | AA874329 | | Note: | | Differences expression in alcohol-preferring and alcohol-nonpreferring mouse strains |
| | Dataset Information | | Name: | | 15282116 | | Method: | | Microarray | | Tissue: | | Striata | | Phenotype: | | Alcohol-nonpreferring, alcohol-preferring, alcohol self-administration | | Publication: | | Saito et al. Alcohol. (2004) Mouse striatal transcriptome analysis: effects of oral self-administration of alcohol. PubMed | | Summary: | | Aiming to define pathways among genomic, neural, and behavioral determinants of addiction, we investigated global striatal gene expression in a paradigm of oral self-administration of alcohol by using genomically very similar alcohol-nonpreferring B6.Cb(5)i(7)-alpha 3/Vad (C5A3) and alcohol-preferring B6.Ib(5)i(7)-beta 25A/Vad (I5B25A) quasi-congenic mouse strains and their progenitors, C57BL/6By (B6By) and BALB/cJ. Expression of 12,488 genes and expressed sequence tags (ESTs) was studied by using 24 high-density oligonucleotide microarrays. As expected, striatal transcriptome differences were far more extensive between the independently derived progenitor strains than between the quasi-congenic strains and their background partner, B6By. |
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