ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

UQCRC2

Full Name:

ubiquinol-cytochrome c reductase core protein II

Alias:

QCR2|UQCR2

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

16p12

Physical Location:

21872109-21902168 on NC_000016.8

Gene Type:

protein-coding

Orthologs:

This gene has Mouse: 67003 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		J04973
Fold Change:		1.5, 1.4
Note:		Differential Expression on the cDNA array (two fold changes are from two case groups)

Dataset Information

Name:		11141048
Method:		Microarray
Tissue:		Frontal cortex
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Lewohl et al. Alcohol Clin Exp Res. (2000) Gene expression in human alcoholism: microarray analysis of frontal cortex. PubMed
Summary:		RNA was extracted from postmortem samples of superior frontal cortex of alcoholics and nonalcoholics. Relative levels of RNA were determined by array techniques. This study used both cDNA and oligonucleotide microarrays to provide coverage of a large number of genes and to allow cross-validation for those genes represented on both types of arrays. Expression levels were determined for over 4000 genes and 163 of these were found to differ by 40% or more between alcoholics and nonalcoholics.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_003366.2	NP_003357.2	NC_000016.8 range: 21872109..21902168

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016020	membrane	Cellular Component	IEA
GO:0005739	mitochondrion	Cellular Component	IEA
GO:0005746	mitochondrial respiratory chain	Cellular Component	IEA
GO:0003824	catalytic activity	Molecular Function	IEA
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (17353931)
GO:0004222	metalloendopeptidase activity	Molecular Function	IEA
GO:0006119	oxidative phosphorylation	Biological Process	TAS (8288258)
GO:0006810	transport	Biological Process	IEA
GO:0009060	aerobic respiration	Biological Process	TAS (8288258)
GO:0006508	proteolysis	Biological Process	IEA