ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Uqcrc2

Full Name:

ubiquinol cytochrome c reductase core protein 2

Alias:

1500004O06Rik

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

7 F2

Physical Location:

127778702-127803036 on NC_000073.5

Gene Type:

protein-coding

Human Ortholog:

GeneID: 7385 Symbol (Name): UQCRC2 (ubiquinol-cytochrome c reductase core protein II)

Ortholog Status:

The human GeneID 7385 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Uqcrc2
Original ID2:		AI842835

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_025899.2	NP_080175.1	NC_000073.5 range: 127778702..127803036

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0016020	membrane	Cellular Component	IEA
GO:0005739	mitochondrion	Cellular Component	IDA (16103131\|16120479)
GO:0005743	mitochondrial inner membrane	Cellular Component	IDA (12865426)
GO:0005746	mitochondrial respiratory chain	Cellular Component	IEA
GO:0003824	catalytic activity	Molecular Function	IEA
GO:0008270	zinc ion binding	Molecular Function	IEA
GO:0046872	metal ion binding	Molecular Function	IEA
GO:0004222	metalloendopeptidase activity	Molecular Function	IEA
GO:0006810	transport	Biological Process	IEA
GO:0006508	proteolysis	Biological Process	IEA