ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Ddit4

Full Name:

DNA-damage-inducible transcript 4

Alias:

5830413E08Rik|AA415483|REDD1|Rtp801|dig2

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

10 B3

Physical Location:

59412422-59414517 on NC_000076.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 54541 Symbol (Name): DDIT4 (DNA-damage-inducible transcript 4)

Ortholog Status:

The human GeneID 54541 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		AI849939
Fold Change:		2.5, 2.0, 2.3, 2.6
Note:		4 fold changes are from C57BL/6J trial 1, C57BL/6J trial 2, DBA/2J trial 1, DBA/2J trial 2

Dataset Information

Name:		15002731
Method:		Microarray
Tissue:		Whole brain
Phenotype:		Acute ethanol response
Publication:		Treadwell et al. Neurochem Res. (2004) Microarray analysis of mouse brain gene expression following acute ethanol treatment. PubMed
Summary:		We have analyzed the expression of approximately 24,000 genes using oligonucleotide microarrays to examine the brain expression profiles in two strains of inbred mice, C57BL/6J and DBA/2J, following exposure to an acute dose of ethanol. Our screen identified 61 genes responding to the ethanol treatment beyond a 1.5-fold threshold, with 46 genes altered in both mouse strains and 15 altered in only one strain.

Gene Information

Original ID1:		Ddit4
Original ID2:		AI849939

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_029083.2	NP_083359.1	NC_000076.5 range: 59412422..59414517, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005575	cellular_component	Cellular Component	ND
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0003674	molecular_function	Molecular Function	ND
GO:0006915	apoptosis	Biological Process	IEA
GO:0008150	biological_process	Biological Process	ND
GO:0009968	negative regulation of signal transduction	Biological Process	IEA