ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Ipo11

Full Name:

importin 11

Alias:

Organism:

Mus musculus (Mouse)

Chromosome:

Genetic Location:

13 D2.1

Physical Location:

107584518-107726994 on NC_000079.5, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 51194 Symbol (Name): IPO11 (importin 11)

Ortholog Status:

The human GeneID 51194 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		Ipo11
Original ID2:		AW124742

Dataset Information

Name:		15745951
Method:		Microarray
Tissue:		Nucleus accumbens, prefrontal cortex, and ventral tegmental area
Phenotype:		Acute ethanol response
Publication:		Kerns et al. J Neurosci. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. PubMed
Summary:		The inbred mouse strains DBA/2J and C57BL/6J exhibit contrasting acute behavioral responses to ethanol. We used oligonucleotide microarrays and bioinformatics methods to characterize patterns of gene expression in three brain regions of the mesolimbic reward pathway of these strains. Expression profiling included examination of both differences in gene expression 4 h after acute ethanol (2 g/kg). Using a rigorous stepwise method for microarray analysis, we identified 307 ethanol-regulated genes in the nucleus accumbens, prefrontal cortex, and ventral tegmental area.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_029665.3	NP_083941.2	NC_000079.5 range: 107584518..107726994, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	RCA (12466851)
GO:0005643	nuclear pore	Cellular Component	IEA
GO:0005737	cytoplasm	Cellular Component	IEA
GO:0005488	binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (11809816)
GO:0008565	protein transporter activity	Molecular Function	RCA (12466851)
GO:0008565	protein transporter activity	Molecular Function	IDA (11809816)
GO:0000059	protein import into nucleus, docking	Biological Process	RCA (12466851)
GO:0006886	intracellular protein transport	Biological Process	IEA
GO:0006810	transport	Biological Process	IEA
GO:0006610	ribosomal protein import into nucleus	Biological Process	IDA (11809816)
GO:0015031	protein transport	Biological Process	IEA