ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

CACNA1D

Full Name:

calcium channel, voltage-dependent, L type, alpha 1D subunit

Alias:

CACH3|CACN4|CACNL1A2|CCHL1A2|Cav1.3

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

3p14.3

Physical Location:

53504115-53821000 on NC_000003.10

Gene Type:

protein-coding

Orthologs:

This gene has no orthologs in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

NM_000720

Dataset Information

Name:		12065639
Method:		Microarray
Tissue:		Frontal and motor cortices
Phenotype:		Alcohol dependence (AD)/Alcohol abuse/Alcoholism
Publication:		Mayfield et al. J Neurochem. (2002) Patterns of gene expression are altered in the frontal and motor cortices of human alcoholics. PubMed
Summary:		We used cDNA microarrays to analyze expression of approximately 10 000 genes in the frontal and motor cortices of three groups of chronic alcoholic and matched control cases. Fluorescent intensity ratios of 1.4-fold or greater in either direction (representing the 99% confidence interval) were used to indicate differentially expressed genes.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_000720.1	NP_000711.1	NC_000003.10 range: 53504115..53821000

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005891	voltage-gated calcium channel complex	Cellular Component	IDA (11160515)
GO:0016020	membrane	Cellular Component	IEA
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0005244	voltage-gated ion channel activity	Molecular Function	IEA
GO:0005509	calcium ion binding	Molecular Function	IEA
GO:0015270	dihydropyridine-sensitive calcium channel activity	Molecular Function	IDA (11160515)
GO:0006811	ion transport	Biological Process	IEA
GO:0006816	calcium ion transport	Biological Process	IDA (11160515)